Pharmax B Complex CWS 0.5 fl oz (15 ml)

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Pharmax B Complex CWS- 0.5 fl oz (15 ml)

• Vitamin B formulation
• Helps the body to metabolize carbohydrates, fats and proteins (1)
• Helps normal growth and development (2)
• Helps to form red blood cells and helps in tissue formation (3)
• Helps to prevent vitamin B12, vitamin B6, thiamine and riboflavin deficiencies (4)
• Ideal for vegans
• Convenient Cold Water Soluable (CWS) liquid format

1 NHPD Monograph on Multivitamin and Mineral. October 2007.
2 NHPD Monograph on Multivitamin and Mineral. October 2007.

Additional product info:
The B vitamins folate, vitamin B6 (pyridoxine), and vitamin B12 (cobalamin) are important regulators of homocysteine metabolism in the body, and randomized controlled trials have demonstrated that supplementation with folate at doses up to 500 µg daily alone or in combination with vitamins B6 and B12 significantly reduces blood homocysteine concentrations (3). Epidemiological evidence suggests that total plasma homocysteine level is an independent cardiovascular risk factor and may have a potential role with regard to outcome after coronary interventions. Studies on the pathogenesis of homocysteine-induced vascular damage have suggested adverse interaction with vascular smooth muscle cells, endothelium function, plasma lipoproteins, and coagulation cascade. A study provides evidence that homocysteine-lowering therapy with folic acid (1 mg/d), vitamin B12 (cyanocobalamin, 400 µg/d), and vitamin B6 (pyridoxine hydrochloride, 10 mg/d) for 6 months improves outcome after percutaneous coronary intervention (4).

Elderly individuals are susceptible to neurodegenerative diseases that are characterized by cognitive and emotional dysfunction, and severe cortical and subcortical deterioration. Previous studies have reported that high concentrations of homocysteine and lower concentrations of vitamin B6, B12, and folate increase the risk for cognitive decline and pathology in aging populations. Using an optimized voxel-based morphometry (VBM) method and global gray and white matter volume after correcting for age, sex, body mass index, calorie intake, and education, a study showed that adults with greater vitamin B6 (27 mg total) intake had greater gray matter volume along the medial wall, anterior cingulate cortex, medial parietal cortex, middle temporal gyrus, and superior frontal gyrus, whereas people with greater B12 (63.2 µg total) intake had greater volume in the left and right superior parietal sulcus. This study provides intriguing results for the use of B vitamin intake on brain volume and adds to a growing literature on the inverse relationship between vitamin B6, B12, and folate (1927 µg total) on tHcy levels and the risks and effects of tHcy and vitamin intake on cognition and the brain in both pathological and non-pathological aging populations (5).

A small study demonstrated a progressive and marked improvement of motor capacity in consecutively evaluated patients with sporadic Parkinson’s disease (PD) who started with below normal laboratory indexes of riboflavin and who eliminated red meat from their diets while receiving high multiple daily doses of riboflavin orally (30 mg every 8 hours) over a period of 6 months while taking their usual symptomatic medications (6).

3 Larsson SC, Männistö S, Virtanen MJ, Kontto J, Albanes D, Virtamo J. Folate, vitamin B6, vitamin B12, and methionine intakes and risk of stroke subtypes in male smokers. Am J Epidemiol. 2008 Apr 15;167(8):954-61.
4 Schnyder G, Roffi M, Flammer Y, Pin R, Hess OM. Effect of homocysteine-lowering therapy with folic acid, vitamin B12, and vitamin B6 on clinical outcome after percutaneous coronary intervention: the Swiss Heart study: a randomized controlled trial. JAMA. 2002 Aug 28;288(8):973-9.
5 Erickson KI, Suever BL, Prakash RS, Colcombe SJ, McAuley E, Kramer AF. Greater intake of vitamins B6 and B12 spares gray matter in healthy elderly: a voxel-based morphometry study. Brain Res. 2008 Mar 14;1199:20-6.
6 Coimbra CG, Junqueira VB. High doses of riboflavin and the elimination of dietary red meat promote the recovery of some motor functions in Parkinson's disease patients. Braz J Med Biol Res. 2003 Oct;36(10):1409-17.

Other ingredients: Glycerol, purified water, sodium carbonate, sodium bicarbonate