Genestra Super EFA Liquid Plus CoQ10 6.8 fl oz (200 ml)

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Genestra Super EFA Liquid Plus CoQ10- 6.8 fl oz (200 ml)

 

• Essential fatty acids formula from fish oils • 1640 mg of EPA + DHA per dose • Includes Coenzyme Q10 derived from bacterial fermentation • Helps to maintain and support cardiovascular health • An all-natural source from Japan • Natural EPA and DHA enrichment • NEO-3™ enzymatic process mimics the natural digestive system • Efficacy, stability & superb palatability • Great tasting natural orange flavor • Natural enrichment process delivers cleaner taste • Includes natural mixed tocopherols for enhanced stability • Independently tested & certified • Meet or exceed Health Canada and FDA regulations • Ensure content claims, meet or exceed label specifications • Environmentally sustainable • Regulated fishery partners and waste reduction methods maximizes the full use of harvested fish

Super EFA Liquid Plus CoQ10 is a unique blend of fish oils from sardine and anchovy to specifically assist support cognitive health and brain function and to maintain overall cardiovascular health, particularly in reducing high serum triglycerides/triacylglycerols levels. Super EFA Liquid Plus CoQ10 contains eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) from sardine and anchovy oils in a EPA:DHA ratio of 1.4:1 that supports cardiovascular health. Super EFA Liquid Plus CoQ10 is naturally flavored with sweet orange oil. It is a source of omega-3 fatty acids, EPA and DHA for the maintenance of good health. Helps support the development of brain, eyes and nerves in children up to 12 years of age.(1)

Naturally sourced from Japan, the CoQ10 in this formula provides an antioxidant required by tissues and organs to maintain and support cardiovascular health.

References: 1. NHPD Monograph on Fish Oil. March 2009.

Additional product info: Fish oils may improve cardiovascular health by altering lipid metabolism, inducing haemodynamic changes, decreasing arrhythmias, modulating platelet function, improving endothelial function and inhibiting inflammatory pathways.(2) In fact, fish oil is recognized by the NHPD of Health Canada to help support and maintain cardiovascular health and to help reduce serum triglycerides/triacylglycerols.(3) Eicosapentaenoic acid (EPA; 22:5n-3) and docosahexaenoic acid (DHA; 22:6n-3) are the 2 principal omega-3 fatty acids in marine oils. Recent data from human studies showed that these 2 fatty acids have differential effects on serum glucose (4 grams EPA), blood pressure (4 grams DHA), heart rate (4 grams DHA) and endothelial function.(4) EPA and DHA alter membrane fluidity, interact with transcription factors such as PPAR and sterol regulatory element binding protein, and are substrates for enzymes including cyclooxygenase, lipoxygenase and cytochrome P450.(5) Studies also show that EPA and DHA (1.6-2.0 grams EPA and 0.9-1.2 grams DHA) found in fish oils generate bioactive lipid mediators that reduce inflammation and polymorphonuclear leukocyte recruitment in numerous inflammatory disease models.(6. 7) While both EPA and DHA decrease TAG levels, only DHA appears to increase HDL and LDL particle size. Evidence to date also suggests that 2.8-4 grams DHA is more efficient in decreasing blood pressure, heart rate and platelet aggregation compared to EPA.(8) Thus, reduction of postprandial triacylglycerol (TG) concentration may be cardioprotective. Studies have shown that chronic omega-3 fatty acid supplementation (4 grams of either EPA or DHA) significantly lowers postprandial TG concentrations regardless of the type of fat in test meal.(9) EPA and DHA are also crucial to brain development and normal brain functioning. DHA is particularly important to brain functioning due to its influence on neural membrane properties, which modulate cell signalling. DHA concentration in the brain decreases with age in humans and this has been postulated to be consequential to the age-related deterioration in central nervous system functions.(10) As such, fish oil supplementation supports the development of the brain, eyes and nerves in children up to 12 years of age and helps support cognitive health and brain function.(11)

Coenzyme Q10 (CoQ10) is a fat-soluble, vitamin-like, ubiquitous compound that functions as an electron carrier in the mitochondrial respiratory chain, as well as serving as an important intracellular antioxidant. CoQ10 protects phospholipids and mitochondrial membrane proteins from peroxidation and protects DNA against the oxidative damage that accompanies lipid peroxidation. CoQ10 concentration in blood cells was analyzed by HPLC and compared to plasma concentration before, during, and after CoQ10 (3 mg/kg/day) supplementation to human probands. Lymphocyte DNA 8-hydroxydeoxy-guanosine (8-OHdG), a marker of oxidative stress, was analyzed by Comet assay. Subjects supplemented with CoQ10 showed a distinct response in plasma concentrations after 14 and 28 days. Plasma levels returned to baseline values 12 weeks after treatment stopped. The plasma concentration increase did not affect erythrocyte levels. However, after CoQ10 supplementation, the platelet level increased; after supplementation stopped, the platelet level showed a delayed decrease. A positive correlation was shown between the plasma CoQ10 level and platelet and white blood cell CoQ10 levels. During CoQ10 supplementation, delayed formation of 8-OHdG in lymphocyte DNA was observed; this effect was long-lasting and could be observed even 12 weeks after supplementation stopped. Intracellular enrichment may support antioxidative defense mechanisms.(12)

References: 2. Cottin SC, Sanders TA, Hall WL. The differential effects of EPA and DHA on cardiovascular risk factors. Proc Nutr Soc. 2011 May;70(2):215-31. Abstract; Page 225 Conclusion 3. NHPD Monograph on Fish Oil. March 2009. 4. Woodman RJ, Mori TA, Burke V, Puddey IB, Watts GF, Beilin LJ.Effects of purified eicosapentaenoic and docosahexaenoicacids on glycemic control, blood pressure, and serum lipids in type 2 diabetic patients with treated hypertension.Am J ClinNutr. 2002 Nov;76(5):1007-15. Page 1007, Introduction 5. Cottin SC, Sanders TA, Hall WL. The differential effects of EPA and DHA on cardiovascular risk factors. ProcNutr Soc. 2011 May;70(2):215-31. Abstract; Page 225 Conclusion 6. McDaniel, J.C., Massey, K. and Nicolaou, A. Fish oil supplementation alters levels of lipid mediators of inflammation in microenvironment of acute human wounds.Wound Repair Regen. 2011 Mar- Apr;19(2):189-200. Page 189, Abstract & Introduction 7. van der Meij, B.S., Langius, J.A., Smit, E.F., Spreeuwenberg, M.D., von Blomberg, B.M., Heijboer, A.C., Paul, M.A. and van Leeuwen, P.A. Oral nutritional supplements containing (n-3) polyunsaturated fatty acids affect the nutritional status of patients with stage III non-small cell lung cancer during multimodality treatment . J Nutr. 2010 Oct;140(10):1774-80. Page 1775, 2nd paragraph 8. Cottin SC, Sanders TA, Hall WL. The differential effects of EPA and DHA on cardiovascular risk factors. Proc Nutr Soc. 2011 May;70(2):215-31. Abstract; Page 225 Conclusion 9. Park, Y. and Harris, W.S. Omega-3 fatty acid supplementation accelerates chylomicron triglyceride clearance.J Lipid Res. 2003 Mar;44(3):455-63. Page 455, Introduction 10. Danthiir V, Burns NR, Nettelbeck T, Wilson C, Wittert G. The Older People, Omega-3, and Cognitive Health (EPOCH) trial design and methodology: A randomised, double-blind, controlled trial investigating the effect of long-chain omega-3 fatty acids on cognitive ageing and wellbeing in cognitively healthy older adults. Nutr J. 2011 Oct 20;10(1):117. Page 2, Background, 2nd paragraph 11. NHPD Monograph on Fish Oil. March 2009. 12. Niklowitz P, Sonnenschein A, Janetzky B, Andler W, Menke T. Enrichment of coenzyme Q10 in plasma and blood cells: defense against oxidative damage. Int J Biol Sci. 2007 Apr 5;3(4):257-62