Genestra Silymarin- 60 capsules

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Genestra Silymarin- 60 capsules

Suggested Retail: $27.95

• 250 mg of milk thistle
• Milk thistle fruit standardized extract
• Helps support liver function
• Traditionally used in Herbal Medicine as a hepatoprotectant/liver protectant, to support liver function and to help relieve digestive disturbances/dyspepsia(1, 2)
• Ideal for vegans
• Convenient capsule format increase patient compliance

References: 1-2. NHPD Monograph on Milk Thistle. June 2009.

Additional product info:
Milk thistle or its purified extract, silymarin (Silybum marianum), is widely used in treating acute or chronic hepatitis. In Herbal Medicine, Milk thistle seed at 3-14.5 grams per day or Silymarin at 140-600 mg per day silymarin (calculated as silibinin/silybin) has been used to help support liver function, traditionally used as hepatoprotectants and used to help relieve digestive disturbances and dyspepsia.(3,4) A randomized, placebo-controlled trial in which participants, treating physicians and data management staff were blinded to treatment group was performed to determine whether silymarin improves symptoms, signs and laboratory test results in patients with acute clinical hepatitis, regardless of etiology. The intervention consisted of three times daily ingestion of either a standard recommended dose of 140 mg of silymarin or a vitamin placebo for four weeks with an additional four-week follow-up. The primary outcomes were symptoms and signs of acute hepatitis determined via results of liver function tests on days 2, 4 and 7 and weeks 2, 4, and 8. Patients receiving silymarin had earlier improvement in subjective and clinical markers of biliary excretion. The results suggest that standard recommended doses of silymarin are safe and may be potentially effective in improving symptoms of acute clinical hepatitis.(5)
Eighty patients on hemodialysis were randomized into four groups to evaluate the effects of Silymarin and/or vitamin E on Oxidative Stress (OS) markers and hemoglobin levels in patients on hemodialysis. Group 1 received silymarin 140 mg 3 times daily; Group 2 received vitamin E 400 IU/day; Group 3 received silymarin 140 mg 3 times daily and vitamin E 400 IU/day; and Group 4 was the control. Oral supplementation with silymarin alone or in combination with vitamin E leads to reduction in malondialdehyde (MDA), increase in red blood cell (RBC) glutathione peroxidase (GPX), and increase in hemoglobin levels.(6)

References:
3-4. NHPD Monograph on Milk Thistle. June 2009.
5. El-Kamary SS, Shardell MD, Abdel-Hamid M, Ismail S, El-Ateek M, Metwally M, Mikhail N, Hashem M, Mousa A, Aboul-Fotouh A, El-Kassas M, Esmat G, Strickland GT. A randomized controlled trial to assess the safety and efficacy of silymarin on symptoms, signs and biomarkers of acute hepatitis. Phytomedicine. 2009 May;16(5):391-400.
6. Roozbeh J, Shahriyari B, Akmali M, Vessal G, Pakfetrat M, Raees Jalali GA, Afshariani R, Hasheminasab M, Ghahramani N. Comparative effects of silymarin and vitamin E supplementation
on oxidative stress markers, and hemoglobin levels among patients on hemodialysis. Ren Fail. 2011;33(2):118-23.

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