Genestra Multi Glyco- 60 Capsules

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Genestra Multi Glyco- 60 Capsules

Suggested Retail: $23.75

• Comprehensive multi vitamin, mineral, botanical and glandular formulation in tablet format
• Chromium provides support for healthy glucose metabolism, while other ingredients maintain immune function and help the body to metabolize carbohydrates, fats and proteins (1)
• Easy-to-use
• One tablet daily with a meal ensures patient compliance

Multi Glyco combines chromium with synergistic vitamins, minerals, herbs and glandular tissues. Chromium supports healthy glucose metabolism (2).

References:
1 NHPD Monograph on Multi-Vitamin Mineral. October 2007.
2 NHPD Monograph on Multi-Vitamin Mineral. October 2007.

Additional product info:
Chromium (Cr) is an essential element required for normal carbohydrate and lipid metabolism. Signs of Cr deficiency have been documented on numerous occasions, including elevated blood glucose, insulin, cholesterol and triglycerides, and decreased high density lipoproteins (HDL) in humans consuming normal diets. A review reports that the response to Cr supplementation for glucose, insulin, lipids, and related variables is related to the amount and form of supplemental Cr, the degree of glucose intolerance, and the duration of the study. Subjects with glucose intolerance but not diabetes usually respond to 200 µg of Cr daily as Cr chloride or other more bioavailable forms of Cr (3). The NHPD recommendations for chromium supplementation in adults to provide support for healthy glucose metabolism are between 2.2-500 µg per day (4).

Adequate zinc status is critical for immune function. Zinc deficiency reduces generation of T cells, depresses humoral and cell-mediated immunity, leads to lymphopenia and thymic atrophy, and increases the frequency and number of infections (5). About 30% of the world’s population is zinc deficient, most prevalent in children under 5 years of age in developing countries. Zinc deficiency is associated with impaired immune function which results in an increase in morbidity due to infections, growth retardation, hypogonadism and cognitive dysfunction (6). A prospective, randomized, controlled clinical trial was conducted involving 231 HIV-infected adults with low plasma zinc levels, who were randomly assigned to receive zinc (12 mg of elemental zinc for women and 15 mg for men) or placebo for 18 months. Zinc supplementation given to HIV-infected adults resulted in a 4-fold decrease in the likelihood of immunological failure, defined as a decrease of CD4+ cell count to

Beta-carotene is a source of Vitamin A to help maintain eyesight, skin, membranes and immune function (9).

Selenium is an antioxidant for the maintenance of good health (10). In a prospective, randomized study design, immunological changes in free-living, healthy aged humans (57-84 years of age) given a placebo, beta-carotene (45 mg/day), and/or selenium (400 µg/day) supplement for 6 months and after 2 months of discontinuation were evaluated. Selenium and selenium plus beta-carotene supplementation caused an increase in total T cells. The study found that selenium enhanced immune function (NK cell cytotoxicity) and phenotypic expression of T-cell subsets, whereas beta-carotene affected only immune function (11).

Aging is accompanied by a variety of physiological, psychological, economic and social changes that compromise nutritional status and/or affect nutritional requirements. For these reasons, the diets of many older adults do not currently meet the recommended intake levels of several essential vitamins and minerals; thus, low micronutrient status is often reported in this population. Nutritional status surveys of the elderly indicate a low to moderate prevalence of frank nutrient deficiencies, but an increased risk of malnutrition, along with evidence of subclinical deficiencies having a direct impact on physiologic function. Overt micronutrient deficiencies have been reported as prevalent in nursing home populations, and recommendations were made that all institutionalized older adults receive a multivitamin/mineral supplement for general nutritional prophylaxis. A clinical study has shown that multivitamin treatment for 8 weeks significantly increased, compared to placebo, plasma concentrations of vitamins D, E, pyridoxal phosphate, folate, B12, C, and improved the riboflavin activity coefficient. Supplementation with a multivitamin formulated at about 100% Daily Value can thus decrease the prevalence of suboptimal vitamin status in older adults and improve their micronutrient status to levels associated with reduced risk for several chronic diseases (12).
Attributes of Multi Glyco covered by the NHPD Monographs: An antioxidant for the maintenance of good health. Helps in the development and maintenance of night vision, bones, cartilage, teeth and gums; helps the body to metabolize carbohydrates, fats and proteins and provides support for healthy glucose metabolism; helps in wound healing and in normal growth and development; helps to form red blood cells, tissue and connective tissue; source of vitamin A to help maintain eyesight, skin, membranes, and immune function.

References:
3 Anderson RA. Chromium, glucose intolerance and diabetes. J Am Coll Nutr. 1998 Dec;17(6):548-55. Page 548, Introduction, 1st paragraph; Page 553, Summary, 1st paragaph
4 NHPD Monograph on Multi-Vitamin Mineral. October 2007.
5 Baum MK, Lai S, Sales S, Page JB, Campa A. Randomized, controlled clinical trial of zinc supplementation to prevent immunological failure in HIV-infected adults. Clin Infect Dis. 2010 Jun 15;50(12):1653-60. Abstract; Page 1653, 1st paragraph;Page 1657, Discussion, 1st paragraph; Page 1658, Conclusion
6 Yakoob MY, Theodoratou E, Jabeen A, Imdad A, Eisele TP, Ferguson J, Jhass A, Rudan I, Campbell H, Black RE, Bhutta ZA. Preventive zinc supplementation in developing countries: impact on mortality and morbidity due to diarrhea, pneumonia and malaria. BMC Public Health. 2011 Apr 13;11 Suppl 3:S23.
7 Baum MK, Lai S, Sales S, Page JB, Campa A. Randomized, controlled clinical trial of zinc supplementation to prevent immunological failure in HIV-infected adults. Clin Infect Dis. 2010 Jun 15;50(12):1653-60. Abstract; Page 1653, 1st paragraph;Page 1657, Discussion, 1st paragraph; Page 1658, Conclusion
8 Mulder TP, van der Sluys Veer A, Verspaget HW, Griffioen G, Peña AS, Janssens AR, Lamers CB. Effect of oral zinc supplementation on metallothionein and superoxide dismutase concentrations in patients with inflammatory bowel disease. J Gastroenterol Hepatol. 1994 Sep-Oct;9(5):472-7. Abstract (Article to be obtained)
9 NHPD Monograph Multi-Vitamin Mineral. October 2007.
10 NHPD Monograph Multi-Vitamin Mineral. October 2007.
11 Wood SM, Beckham1 C, Yosioka2 A, Darban3 H, Watson RR. beta-Carotene and selenium supplementation enhances immune response in aged humans. Integr Med. 2000 Mar 21;2(2):85-92. Abstract (Article to be obtained)
12 McKay DL, Perrone G, Rasmussen H, Dallal G, Hartman W, Cao G, Prior RL, Roubenoff R, Blumberg JB. The effects of a multivitamin/mineral supplement on micronutrient status, antioxidant capacity and cytokine production in healthy older adults consuming a fortified diet. J Am Coll Nutr. 2000 Oct;19(5):613-21. Abstract; Page 613, Introduction; Page 616, Water-Soluble Vitamins, 1st paragraph

Other ingredients: Microcrystalline cellulose, croscarmellose sodium, magnesium stearate, silica, pharmaceutical glaze

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