Genestra Femagen PMS- 60 capsules

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Genestra Femagen PMS- 60 capsules

Suggested Retail: $22.50

• Multivitamin, mineral and botanical formulation
• Chaste Tree fruit is used in Herbal Medicine to help relieve premenstrual symptoms (1)
• Ideal for vegans
• Convenient capsule format increase patient compliance

Femagen Capsules combines vitamins, minerals, and herbs in a well-balanced formula. Femagen Capsules includes Chaste Tree fruit which is used in Herbal Medicine to help relieve premenstrual symptoms (2). The capsules are 100% pure vegetable-sourced.

References:
1 NHPD monograph on Chaste tree (Vitex agnus-castus). June 2010.
2 NHPD monograph on Chaste tree (Vitex agnus-castus). June 2010.

Additional product info:
Premenstrual syndrome (PMS) is characterized by psychic and somatic symptoms typically occurring in the second part of the female cycle and disappearing with the onset of or during menstrual bleeding. Up to 150 different symptoms have been recorded as part of PMS. According to the scientific literature, the prevalence of PMS is about 30%–40% in fertile women, and 5%–10% suffer from severe complaints. A recent investigation involving students of pharmacy at Basel University (n = 132) revealed a prevalence of 70% regardless of the intake of oral contraceptives. In the last decades, phyto-pharmaceutic preparations containing Vitex agnus castus (VAC) extracts have been used. Vitex (chaste tree, chasteberry) is a bushy plant native to the Mediterranean countries and Asia. Extracts from its fruit (Agni casti fructus) have been used for treating gynecological complaints since Greek antiquity. In a multicenter non interventional trial, data on 1634 women were obtained to assess information about the efficacy and safety of a new Vitex preparation, each capsule containing 1.6–3.0 mg dried extract of Agni casti fructus [6.7–12.5:1], corresponding to 20 mg tested material, used in daily practice for 3 months. More than 40% of all patients reported a complete cessation of all PMS complaints. In 93% of the documented cases, the number of PMS symptoms decreased, and 95% of the patients experienced an improvement, whereas physicians assessed the therapeutic efficacy in 96% of the cases as at least moderate. Vitex was proven to be effective with respect to all psychic and somatic symptoms of the heterogeneous and multifaceted PMS (3). Similar results were obtained with an extract of agnus casti (fruit extract ZE 440: 60% ethanol m/m, extract ratio 6­12:1; standardized for casticin; one 20 mg tablet once daily) in a randomised, double blind, placebo controlled, parallel group comparison over three menstrual cycles in 170 women (mean age of 36 years old) (4). Chaste tree fruit at 30-2,000 mg per day is used in Herbal Medicine to help relieve premenstrual symptoms and as a hormone normalizer to help stabilize menstrual cycle irregularities (5).

Hypericum perforatum (St John's Wort) influences the serotonergic system. A randomized, double-blind, placebo-controlled, crossover study was conducted to investigate the effectiveness of Hypericum perforatum on symptoms of PMS. Women who remained eligible after three screening cycles (n = 36) underwent a two-cycle placebo run-in phase. They were then randomly assigned to receive Hypericum perforatum tablets 900 mg/day (extract ratio 3-6:1, standardized to 0.18% hypericin; 3.38% hyperforin) or identical placebo tablets for two menstrual cycles. After a placebo-treated washout cycle, the women crossed over to receive placebo or Hypericum perforatum for two additional cycles. Hypericum perforatum was statistically superior to placebo in improving physical and behavioral symptoms of PMS (6). Participants took either one St. John’s Wort tablet containing 300 mg extract standardized to 0.3% hypericin or one placebo tablet, three times a day. After 12 weeks of treatment with ethanolic St. John's Wort extract or placebo, a non significant difference favoring the St. John's Wort group was observed in the daily hot flash frequency and the hot flash score. After 3 months of treatment, compared with the placebo group, women in the St. John's wort group reported significantly better menopause-specific quality of life and significantly fewer sleep problems (7).

St. John’s Wort herb tops at 0.6-12.6 grams per day is used in Herbal Medicine as a sedative and calmative to help relieve restlessness and nervousness (8). The German Commission E has approved St. John’s Wort at 2-4 g per day of dried herb tops or 0.2 – 1 mg hypericin for internal use for anxiety and/or nervous unrest (9).

Eleuthero root at 0.91-6 g per day, is used in Herbal Medicine to help improve mental and/or physical performance after periods of mental and/or physical exertion and as a tonic to help relieve general debility or to aid during convalescence (10).
Beta-carotene at 65-3,000 mcg RAE per day is a source of Vitamin A to help maintain eyesight, skin, membranes and immune function (11).

References:
3 Loch EG, Selle H, Boblitz N. Treatment of premenstrual syndrome with a phytopharmaceutical formulation containing Vitex agnus castus. J Womens Health Gend Based Med. 2000 Apr;9(3):315-20. Abstract; Page 315 and 316, Introduction, 1st, 2nd and 4th paragraphs; Page 317, Materials and Methods, 1st paragraph; Page 318, Results, 1st and 2nd paragraphs; Page 319, Discussion, 1st and 3rd paragraphs; Page 320, Conclusion
4 Schellenberg R. Treatment for the premenstrual syndrome with agnus castus fruit extract: prospective, randomised, placebo controlled study. BMJ. 2001 Jan 20;322(7279):134-7. Abstract; Page 135, Methods, 2nd paragraph; Page 137, Conclusion
5 NHPD monograph on Chaste tree (Vitex agnus-castus). June 2010.
6 Canning S, Waterman M, Orsi N, Ayres J, Simpson N, Dye L. The efficacy of Hypericum perforatum (St John's wort) for the treatment of premenstrual syndrome: a randomized, double-blind, placebo-controlled trial. CNS Drugs. 2010 Mar;24(3):207-25. Abstract
7 Al-Akoum M, Maunsell E, Verreault R, Provencher L, Otis H, Dodin S. Effects of Hypericum perforatum (St. John's wort) on hot flashes and quality of life in perimenopausal women: a randomized pilot trial. Menopause. 2009 Mar-Apr;16(2):307-14. Abstract
8 NHPD Monograph on St.John’s Worth Oral. November 2009.
9 Blumenthal, Mark, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Austin, TX: American Botanical Council, 1998.
10 NHPD Monograph on Eleuthero. March 2008.
11 NHPD Monograph on Multi-Vitamin and Mineral. October 2007.

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