Genestra E-400 Emulsified- 120 Capsules

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$42.70
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Genestra E-400 Emulsified- 120 Capsules

Suggested Retail: $36.10

• Vitamin E formulation in a soft gel capsule
• An antioxidant and a factor in the maintenance of good health (1)
• Convenient softgel capsule format
• Increases patient compliance

E400 Emulsified provides a natural source of naturally emulsified vitamin E as an antioxidant and a factor in the maintenance of good health (2).

References:
1 NHPD Monograph on Vitamin E (from RRR-alpha-tocopherol and esters). June 2009.
2 NHPD Monograph on Vitamin E (from RRR-alpha-tocopherol and esters). June 2009.

Additional product info:
Oxidative stress plays an important role in the pathogenesis of cardiovascular disease (CVD). Growing evidence suggest that antioxidant vitamins might reduce the risk of disease outcomes by their ability to scavenge free radicals. A case-control study with vitamin E (400 IU/d) and vitamin C (500 mg/d) supplementation in 40 CVD patients for 2 months showed reduced lipid peroxidation and a strengthened antioxidant defense system. Hence, vitamin E and vitamin C supplementation may have beneficial effects on the heart by reducing oxidative stress in CVD patients (3). In addition, previous epidemiologic studies suggested an inverse relationship between dietary intake and plasma concentrations of vitamin E and risk of cardiovascular disease. Underpinning the interest in the potential ability of antioxidants to prevent cardiovascular disease is the oxidation hypothesis of atherogenesis. A group of researchers defined the dose-dependent effects of vitamin E (RRR-?-tocopherol) to suppress plasma concentrations of F2-isoprostanes, a biomarker of free radical mediated lipid peroxidation, in participants with polygenic hypercholesterolemia and enhanced oxidative stress, a population at risk for cardiovascular events. A time-course study was first performed in participants supplemented with 3200 I.U./day of vitamin E for 20 weeks. A dose-ranging study was then performed in participants supplemented with 0, 100, 200, 400, 800, 1600, or 3200 I.U./day of vitamin E for 16 weeks. In the time-course study, maximum suppression of plasma F2-Isoprostane concentrations did not occur until 16 weeks of supplementation. In the dose-ranging study there was a linear trend between the dosage of vitamin E and percent reduction in plasma F2-isoprostane concentrations which reached significance at doses of 1600 I.U and 3200 I.U (4).

A randomized, double-blind, placebo-controlled trial was conducted to determine the effect of 1 year of vitamin E supplementation on respiratory tract infections in elderly nursing home residents. A total of 617 persons aged at least 65 years and who met the study’s eligibility criteria were enrolled and Vitamin E (200 IU) or placebo capsule were administered daily. Fewer participants receiving vitamin E acquired 1 or more respiratory tract infections or upper respiratory tract infections. When common colds were analyzed in a post hoc subgroup analysis, the vitamin E group had a lower incidence of common cold and fewer participants in the vitamin E group acquired 1 or more colds. Supplementation with 200 IU per day of vitamin E did not have a statistically significant effect on lower respiratory tract infections in elderly nursing home residents. However, a protective effect of vitamin E supplementation on upper respiratory tract infections, particularly the common cold, was observed (5).

Hot flashes affect as many as 75% of menopausal women. Estrogen reliably reduces the severity of hot flashes and remain the single most effective treatment. Today, however, more and more women are seeking alternatives. Instead of hormonal therapy, women are turning to vitamins, and other over-the-counter products for relief from hot flashes. A placebo controlled, double-blind study was undertaken to assess the effect of vitamin E on hot flashes. After 1 week baseline period, the enrolled patients (n = 51) received placebo daily for 4 weeks, followed by 1 week wash out and 400 IU vitamin E daily for the next 4 weeks. There were statistical significant differences in hot flashes severity score and their daily frequency after the treatments between the placebo and vitamin E therapies. Based on this trial, vitamin E is recommended for the treatment of hot flashes (6).

References:
3 Karajibani M, Hashemi M, Montazerifar F, Dikshit M. Effect of vitamin E and C supplements on antioxidant defense system in cardiovascular disease patients in Zahedan, southeast Iran. J Nutr Sci Vitaminol (Tokyo). 2010;56(6):436-40.
4 Roberts LJ 2nd, Oates JA, Linton MF, Fazio S, Meador BP, Gross MD, Shyr Y, Morrow JD. The relationship between dose of vitamin E and suppression of oxidative stress in humans. Free Radic Biol Med. 2007 Nov 15;43(10):1388-93.
5 Meydani SN, Leka LS, Fine BC, Dallal GE, Keusch GT, Singh MF, Hamer DH. Vitamin E and respiratory tract infections in elderly nursing home residents: a randomized controlled trial. JAMA. 2004 Aug 18;292(7):828-36.
6 Ziaei S, Kazemnejad A, Zareai M. The effect of vitamin E on hot flashes in menopausal women. Gynecol Obstet Invest. 2007;64(4):204-7.

Other ingredients: Gelatin (porcine), glycerin, vegetable (soybean) oil, polysorbate 80, purified water

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